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In recent years, the seemingly unstoppable trend for tattoos has brought safety concerns into the spotlight1. Currently, basic toxicological aspects, from biokinetics to possible alterations of the pigments, are largely uncertain. The animal experiments which would be necessary to address these toxicological issues were rated unethical because tattoos are applied as a matter of choice and lack medical necessity, similar to cosmetics2. Consequently, the hazards that potentially derive from tattoos were as yet only investigated by chemical analysis of the inks and their degradation products in vitro3,4,5,6. Even though toxicological data might be available for some ink ingredients individually, information on in vivo interactions of the ink’s components and their fate within the body is rare. 
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